Losartan Potasico - Hydrochlorotiazide Tablets is a blood pressure medicine that regulates its level. The treatment of hypertension is important to lower the workload of heart and arteries. This is a combination medicine that lowers the blood pressure to reduce the risk of heart attack and stroke. This medicine works by relaxing the blood vessels and increasing the supply of oxygen and blood to the heart. It is taken by mouth with or without food.